There has been significant progress in developing targeted therapies for cancers driven by mutations in genes that encode enzymes (e.g. kinases). However, developing effective therapies for cancers that are driven by mutations that do not directly affect a targetable protein represents a major challenge in cancer research. Ras-driven cancers represent an important example of this challenge. We have been taking innovative approaches to develop novel combination therapies for Ras driven tumors and have recently made important advances in developing potential therapies for nervous system malignancies and lung cancer.
Publications
Naiara Perurena, Rebecca Lock, Rachel A. Davis, Srivatsan Raghavan, Natalie F. Pilla, Raymond Ng, Patrick Loi, Caroline J. Guild, Abigail L. Miller, Ewa Sicinska, James M. Cleary, Douglas A. Rubinson, Brian M. Wolpin, Nathanael S. Gray, Sandro Santagata, William C. Hahn, Jennifer P. Morton, Owen J. Sansom, Andrew J. Aguirre, Karen Cichowski
Cell Reports Medicine, 2023 Apr
Amy E. Schade, Ryan Kuzmickas, Carrie L. Rodriguez, Kaia Mattioli, Miriam Enos, Alycia Gardner, Karen Cichowski
PLOS Biology, vol. 21, Public Library of Science, 2023 Apr, pp. 1-21
Ophélia Maertens, Ryan Kuzmickas, Haley E. Manchester, Chloe E. Emerson, Alessandra G. Gavin, Caroline J. Guild, Terence C. Wong, Thomas De Raedt, Christian Bowman-Colin, Elodie Hatchi, Levi A. Garraway, Keith T. Flaherty, Shailja Pathania, Stephen J. Elledge, Karen Cichowski
Cancer Discovery, vol. 9, 2019 Apr, pp. 526-545
Clare F. Malone, Chloe Emerson, Rachel Ingraham, William Barbosa, Stephanie Guerra, Haejin Yoon, Lin L. Liu, Franziska Michor, Marcia Haigis, Kay F. Macleod, Ophélia Maertens, Karen Cichowski
Cancer Discovery, vol. 7, 2017 Dec, pp. 1450-1463
A Collaborative Model for Accelerating the Discovery and Translation of Cancer Therapies
Ophélia Maertens, Mila E. McCurrach, Benjamin S. Braun, Thomas De Raedt, Inbal Epstein, Tannie Q. Huang, Jennifer O. Lauchle, Hyerim Lee, Jianqiang Wu, Timothy P. Cripe, D. Wade Clapp, Nancy Ratner, Kevin Shannon, Karen Cichowski
Cancer Research, vol. 77, 2017 Oct, pp. 5706-5711
Cotargeting MNK and MEK kinases induces the regression of NF1-mutant cancers
Rebecca Lock, Rachel Ingraham, Ophélia Maertens, Abigail L. Miller, Nelly Weledji, Eric Legius, Bruce M. Konicek, Sau-Chi B. Yan, Jeremy R. Graff, Karen Cichowski
The Journal of Clinical Investigation, vol. 126, The American Society for Clinical Investigation, 2016 Jun, pp. 2181-2190
