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Cancer Discovery, 2024
AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution
Schade AE, Perurena N, Yang Y, Rodriguez CL, Krishnan A, Gardner A, Loi P, Xu Y, Nguyen VTM, Mastellone GM, Pilla NF, Watanabe M, Ota K, Davis RA, Mattioli K, Xiang D, Zoeller JJ, Lin JR, Morganti S, Garrido-Castro AC, Tolaney SM, Li Z, Barbie DA, Sorger PK, Helin K, Santagata S, Knott SRV, Cichowski K
Nature, 2024
Combinatorial strategies to target RAS-driven cancers
Naiara Perurena*, Lisa Situ*, Karen Cichowski. *Co-first authors.
Nature Reviews Cancer, 2024
Co-targeting a MYC-eIF4A survival axis improves the efficacy of KRAS inhibitors in lung cancer
Francesca Nardi, Naiara Perurena, Amy E. Schade, Ze-Hua L, Kenneth Ngo, Elena V. Ivanova, Aisha Saldanha, Chendi Li, Prafulla C. Gokhale, Aaron N. Hata, David A. Barbie, Cloud P. Paweletz, Pasi A. Janne, Karen Cichowski
Journal of Clinical Investigation, 2023
Abigail L. Miller, Naiara Perurena, Alycia Gardner, Toshinori Hinoue, Patrick Loi, Peter W. Laird, Karen Cichowski
Cancer Research, 2023 May 18
Naiara Perurena, Rebecca Lock, Rachel A. Davis, Srivatsan Raghavan, Natalie F. Pilla, Raymond Ng, Patrick Loi, Caroline J. Guild, Abigail L. Miller, Ewa Sicinska, James M. Cleary, Douglas A. Rubinson, Brian M. Wolpin, Nathanael S. Gray, Sandro Santagata, William C. Hahn, Jennifer P. Morton, Owen J. Sansom, Andrew J. Aguirre, Karen Cichowski
Cell Reports Medicine, 2023 Apr
Amy E. Schade, Ryan Kuzmickas, Carrie L. Rodriguez, Kaia Mattioli, Miriam Enos, Alycia Gardner, Karen Cichowski
PLOS Biology, vol. 21, Public Library of Science, 2023 Apr, pp. 1-21
A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers
Stephanie L. Guerra, Ophélia Maertens, Ryan Kuzmickas, Thomas De Raedt, Richard O. Adeyemi, Caroline J. Guild, Shawna Guillemette, Amanda J. Redig, Emily S. Chambers, Man Xu, Hong Tiv, Sandro Santagata, Pasi A. Jänne, Stephen J. Elledge, Karen Cichowski
Cancer Cell, vol. 37, 2020, pp. 705-719.e6
Ophélia Maertens, Ryan Kuzmickas, Haley E. Manchester, Chloe E. Emerson, Alessandra G. Gavin, Caroline J. Guild, Terence C. Wong, Thomas De Raedt, Christian Bowman-Colin, Elodie Hatchi, Levi A. Garraway, Keith T. Flaherty, Shailja Pathania, Stephen J. Elledge, Karen Cichowski
Cancer Discovery, vol. 9, 2019 Apr, pp. 526-545
Clare F. Malone, Chloe Emerson, Rachel Ingraham, William Barbosa, Stephanie Guerra, Haejin Yoon, Lin L. Liu, Franziska Michor, Marcia Haigis, Kay F. Macleod, Ophélia Maertens, Karen Cichowski
Cancer Discovery, vol. 7, 2017 Dec, pp. 1450-1463
A Collaborative Model for Accelerating the Discovery and Translation of Cancer Therapies
Ophélia Maertens, Mila E. McCurrach, Benjamin S. Braun, Thomas De Raedt, Inbal Epstein, Tannie Q. Huang, Jennifer O. Lauchle, Hyerim Lee, Jianqiang Wu, Timothy P. Cripe, D. Wade Clapp, Nancy Ratner, Kevin Shannon, Karen Cichowski
Cancer Research, vol. 77, 2017 Oct, pp. 5706-5711
Loss of RasGAP Tumor Suppressors Underlies the Aggressive Nature of Luminal B Breast Cancers
Sarah Naomi Olsen, Ania Wronski, Zafira Castaño, Benjamin Dake, Clare Malone, Thomas De Raedt, Miriam Enos, Yoko S. DeRose, Wenhui Zhou, Stephanie Guerra, Massimo Loda, Alana Welm, Ann H. Partridge, Sandra S. McAllister, Charlotte Kuperwasser, Karen Cichowski
Cancer Discovery, vol. 7, 2017 Feb, pp. 202-217
Cotargeting MNK and MEK kinases induces the regression of NF1-mutant cancers
Rebecca Lock, Rachel Ingraham, Ophélia Maertens, Abigail L. Miller, Nelly Weledji, Eric Legius, Bruce M. Konicek, Sau-Chi B. Yan, Jeremy R. Graff, Karen Cichowski
The Journal of Clinical Investigation, vol. 126, The American Society for Clinical Investigation, 2016 Jun, pp. 2181-2190
